What year is your truck? Most parts suppliers have lower fender patch panels that you can weld on. If you have never done body work before you might want someone to help you do it. On my truck a lower rear panel was around $35-$40 vs. replacing the fender for $350
It depends on how much a new part is and how much it would cost to repair the old one. Almost anything can be repaired, but the question is, is it worth it?