Go to the library and pick up the book Super Tuning and Modifying Holley Carburetors.
First and foremost, each engine is different, so there is no canned answer.
Here is my process
Make sure that you do not have any vacuum leaks
Is the carb vacuum or mechanical secondaries? If vacuum, you may need to tune the spring rate. If it is mechanical, then you may be feeding it more than needed for a street engine.
Check vacuum at idle. Then size the power valve accordingly. Generally take the vacuum reading at idle, and divide by 2. This will get you close to the right number. usually a 7.5 or 8.5 for the street (engine dependent). Do this first.
With the engine timing set properly proceed to the following
With the air cleaner on, and choke fully open, lean out the idle mixture screws until the RPM starts to drop, then open just slightly, then using a propane torch, introduce a bit of propane to the air filter. adjust the screws until the RPM's start to drop a bit with the you are looking for no more than a 25 rpm drop with the propane. This will get your idle mixture close to stoich
for adjusting vacuum secondaries, use a paperclip on the actuator rod located at the top. take the vehicle for a ride and do a full load hole shot. Measure the spring movement by seeing how far the paperclip moved. if the secondaries are not opening all the way, then you need to adjust the spring.
For jets, you will need to play with them to get proper sizing. I have had two nearly identical installations, where I had 64's on the primary of one, and 61's on the other. You are looking for good throttle response. I would start with a set of 58's and go 2 sizes larger each change until it starts to stumble off idle. Then drop one size. Repeat for the secondaries, however that is usually at wide open throttle.
beyond that, you will have to dig more into the book.
