When my '54 3/4 ton was a daily driver, I was getting about 12 mpg city and 14-16 mpg highway.
If I pushed it over 50 MPH for any legnth of time, the fuel mileage went WAY down...
Stock 235, Rochester B, 3-speed, 4.57 rear, 7.50 x 15 tires.
Just drove my '72 C-10 long-box with 250 six, 3-sp, on a long trip (400 miles); kept my foot outta the carb (65mph or less) on the way down, and was surprised to actually get 18 mpg.