There won't be enough selector positions to align with all the gear positions, so you'll have to count clicks to get to the right gear. Also, the Powerglide shift pattern is P-N-D-L-R, so a car thief would get terribly confused trying to find the right gear! I used to drive the family's 63 Impala with a 327/PG setup 100+ MPH pretty often, so highway speeds with a PG won't be a problem with an engine that can stand the RPM.
Jerry