The 350 Auto will bolt up to your 250 engine but you need to consider transmission mounts, cooler & lines, shifter, and of course driveshaft mods. It will not however improve your freeway speeds as it like all non overdrive transmissions are 1:1 in high gear. As Frank mentioned the T-5 is a good option and there are a number of other overdrive options all of which require some modifications to various components and sometimes a substantial cash outlay.
Fred

Last edited by rfs56trk; 02/19/2008 6:45 PM.

1956 3100 Pickup/Red/350/3sp OD/PS/Disc Brakes
1957 Bel Air Sport Coupe/Red/355/TH350/PS/Disc Brakes
2017 Silverado LT Single Cab SB/Black/5.3/6 Speed Trans
1947 Willys CJ2A w/F-Head engine