Depends on many factors. If the engine has not been rebuilt with insert rod bearings, I would leave the stock manifold on. With insert bearings and a full flow oil system, I would consider either a split manifold or cast headers. If you have a hotter cam, headers and intake change is a must to reach the potential of the cam. Also remember that you will loose some low end torque with any of these changes. The 216, in it's original configuration, doesn't handle higher rpms or aggressive acceleration. If you really want to warm a 216 over, take a look at the older books on hot rodding Chevy 6's, written in the early 50's. They were available on Amazon.