As far as most practical, the cummins 4BT, that's like in the dodge truck but only 4 cylinders.
The 6 cylinder from the dodge is going to be too long to make it an easy conversion, and you will want a 1 ton truck or better to start with, or at least I would.
I am doing the Detroit 4-53T conversion, check out the pictures on the link below.
Grigg