Drilling the manifold boss will require you finding the correct offset bracket to mount the horn there. If it fits in the firewall location, then that would work fine.

I think there'd be plenty of room to drill the boss. As I mentioned you might need a slightly longer drill bit to keep the chuck from hitting the manifold. The attached pic shows a standard length 19/64" drill bit chucked all the way into the drill. You might be able to chuck the bit shallower and avoid hitting the manifold with the chuck.
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Kevin
1951 Chevy 3100 work truck
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1929 Ford pickup restored from the ground up. | 1929 Ford Special Coupe (First car)
Busting rust since the mid-60's
If you're smart enough to take it apart, you darn well better be smart enough to put it back together.