For an older working truck the best frame is the one it came with.
If you have a small truck and only want to use it as a car then perhaps an S10 is a good fit, but for real trucks I think a real frame is best.
If you plan to use it to haul one of your other trucks you don't need to do anything to it except get it running and stopping, the rest is built for the job.
If you would like better brakes, and the option of more rear gear choices check my picture link below.
The only upgrade I can think of that may help the actual suspension would be a sway bar. I will try to put one or two on my truck before I am done, but have not started that project yet. I do have a sway bar from a 94 Chevy TopKick 4500 that I think may work for the front, or for sure the rear. Whatever I end up using It will be from a full sized pickup or a medium duty truck. I'll keep y'all informed when I start on the sway bar.
Grigg