I'm with Mark. If you find minor rust under the seals, I'd wire brush the area and use something like Rustoleum Red primer to slow it down. You can get that in a pint can and brush it on in the areas that need it so you don't have to worry about overspray. Or use a rattle can and mask the area.
If you don't see rust around the windshield and rear window seals, I wouldn't mess with them currently. I'm not seeing a problem around your windshield in your photo.
That right side rain gutter is starting to look a bit ugly, though.
If you want to drive it, don't start tearing thing apart. I'm 8 years after buying my truck into a full restoration, and still not quite done. But the idea for mine was something to work on during retirement. It has accomplished that goal, for sure.
