You probably want it to go off when the ign. is shut off. If so wire the fuse to the ign. switch.
George
There are probably times when you want 4 way flashers (if available on the system used) when the truck is shut off (as in dead on the side of the road). So a constantly powered source would be needed for that. If it's just turn signals, then a key-on powered source would be best.