Thanks for the replies.
From the linked threads it sounds like I should get a noticeable improvement.
I wasn't remembering the floor mat going up past the pedals, those and the shifter and brake handle would be the only concerning obstacles to that endeavor. I would likely slit the firewall pad however needed to get it installed.
I've been plugging some holes with some rubber grommet/plugs I had, still some to go though.
Anyone seal up the door hinge holes? Those look like they are inboard of the exterior door seals and could allow rodents in, or is the cavity where the door hinge jamb is not accessible to rodents?
Another area I've been wondering about is behind the seat at the cab corners, stuff can fall down in those holes and basically be down there forever. Dirt, nests, bugs, water, whatever - with no way to fall or drain on out the bottom. What is everyone doing about that area? I have yet to sacrifice the shop vac by sticking it down in the hole to see what it pulls out of it.