The S10 frame would be plenty strong, even with a V8. The S truck frame is more or less a '78 Malibu frame from the cab mount forward, so it was designed with V8 power in mind. The actual basic design actually even dates back to the original Chevelle from '64, and that basic chassis used everything from a 230 6 up to the 450 horse 454.
I can see 4 drawbacks to using the Dodge frame; 1-the engine has to be mounted approximatly 4" to the right to allow for steering shaft clearance. 2- they are a real pain in the butt to get the alignment settings correct, namely camber and caster, due partly to the upper control arm design (slip shafts) and also on the right side due to the engine offset, especially with a V8. 3- the Dakota is very bad about balljoint failure. Chrysler had a huge recall a few years back because of this. It's a poor part design. And 4-oddball wheel bolt pattern on the later models. It's a 6 lug, but it's a 4 1/2" bolt circle. Makes wheel fitment very iffy and lowers the selection. Early models use the 5x4 1/2 ford/mopar pattern.
I'm not going to say it can't be done, just giving a heads up to some of the issues with that particular frame.
