Well, conjecture has it that the outside door lock was on the right side because in city/town/village street-side parking, it is unsafe exit/enter the truck on the driver's side. I have see movies with stovebolts that show the driver getting out and/or getting in a the passenger side.
My bs theory for the tire on the driver's side is that only a fool would try to change a tire on-or-near the side a two-lane road. This tire location forces the driver to completely pull off the road to safely change the tire?