If you mean Trailblazer frame, initial numbers seen not too crazy but still not a great fit

Wheelbase 113 in (S-10 118 in, 41-46 115")
Length 191.8 in (41-46 199 3/16)
Track width 63-61 in (S-10 55-59 in, can't find an exact number for the total width of a 46 or the track width)
Frame width Quick search didn't show anything regarding this info

If you're saying the running gear, then that's a waste of time since I'd be getting rid of the engine, accessories, radiator, transmission and altering the driveshaft to fit the electric motor.

100 lb isn't too bad, it is 5% of my final weight goal though. I'm hoping to measure someone's truck in person to determine exactly how much I can trim from the front of the rear fender to the front of the bed (and correspondingly, wheelbase), and how much room that leaves for batteries since there need to be 3 compartments. Behind axle, and to either side of the driveshaft.