My grandfather ran 1935 1 1/2 tons set up as tractor trailers from Nashville to St. Louis and Milwaukee and back, hauling beer in the late 1930's so long distances weren't impossible. There's an Oldsmobile or Pontiac connecting rod bearing that can be used to convert those Babbit rods to insert-type bearings after some pretty careful machining, and I've seen a few reconditioned 206 rods for sale on Ebay. It would be expensive to build that engine, but not impossible. Getting it up to highway speed would be dangerous, if not impossible due to the low-geared rear axle.
Jerry