If you are going to use a two-barrel, what you don't want is a 2->1 adapter. Gasoline and air mixed do NOT like extra corners (think about an older river with curves.......where is the current???). We did quite a bit of testing 2->1 adapters years ago, with negative results.
Can it be made to work? Yes, it can. Internal combustion engines are remarkable flexible. You can even get one to run by having a 15-year-old stand on the running board and, with the hood off, pour gas into the engine out of a leaky boot!

How well will it work, compared to an engineered system??? I would rather have the 15-year-old!
If you absolutely have to have a two-barrel, fabricate a new intake manifold with a plenum large enough to accomodate the air/fuel flow from the two-barrel DIRECTLY INTO THE PLENUM, with space around the outside of the air flow.
And you might check the second line in my signature

Jon.