What rims are you running? What kind of offset?
Everything which I have read about the S10 frame swap for an AD recommended that spacers be used on the front to bring the wheels outward.
They also recommend using an S10 4WD rear end because the 2WD S10 rear axle is too narrow.
Something odd may be going on with what you have.

1952 5-window - return to "as built" condition | 1950 3100 with a 235 and a T-5 transmission