Look a little beyond the basic alignment angles such as caster, camber, and toe. Dropped spindles affect such things as roll center, roll couple, scrub radius, and Ackerman. Making a simple change such as going to a different anti-roll bar, or changing its position can induce all sorts of unpredictable handling characteristics in a turn.
Rear suspension design also does a lot more than just hold up the back end of the vehicle, and rear roll centers, etc. can have a lot of influence on handling. Let me strongly suggest that you read everything you can about suspension and steering design before you start whittling and welding. You'll probably save yourself a lot of time and money and end up with a reliable, safe vehicle that will do exactly what you want if you make it work on paper first. The round track race cars I built for a few decades went through that exact process before we ever put a torch or a saw to the first piece of metal.
Straight ahead driving probably won't be affected, but getting into an unexpected tight turn with a loaded trailer isn't going to be the time to discover your engineering wasn't quite as good as you thought. Now, pretty soon, a few people who wear their feelings on their sleeve are going to accuse me of being an unfeeling old goat who spends every day looking for somebody's bubble to burst, and their agonized screams of anguish will be something to behold. We should really consider having an official Stovebolt.com crying towel for those guys. I spent 30-something years teaching high school kids who had been abandoned by the public education system to be productive, taxpaying members of society as ASE-certified auto mechanics, so those comments don't bother me at all.
As long as you go into your project with an open mind and a willingness to at least listen to the advice of some of us who have spent a lifetime making a living in the automotive business, we'll get along just fine. Whether of not you choose to heed that advice is up to you.
If you're one of those guys who get their lacy drawers in a wad anytime something other than fawning praise for your project comes your way, go ahead and think whatever you will of me. Just take note of the sprig of mistletoe attached to my shirt tail!
Jerry