Off hand, I’m going to say the later chassis will be a little wide. The 4100 and larger trucks had wider and longer fenders. It may be worthwhile to find a “Big Bolt” donor. I’ve also seen the low rider guys narrow their control arms. Unless you’re bagging it, I would guess it would create a terrible ride.
Is your 1950 a 3800 truck? In my opinion, the 3800 trucks are beefier than even the late model trucks.
