Dave, the standard 5 screw sender flange has a rubber gasket. This gasket is very adequate. It's only splash "pressure". It won't leak. The screws won't leak.
If I had a AD, I would use/modify a TF sender/pickup. They draw from the top. So do 60-66. Plug the tank at bottom with pipe plugs, no valve. The 59 motor you have in the 50 has a fuel pump designed to draw from a top outlet sender. So no worries there. These say they work with your tank. 49-53 and 54-59 ???
check it outHave not read on here that anyone has used this on 49-53. But the web says it works. This style avoids leaks in cab.