My 49 3100 w/it's stock 216 and 4:11 rear goes 60 to 100 miles every Saturday, barring rain or snow. Avg speed is 45 which is a little over 2K rpm but it does hit a stretch of 55 mph and the occasional passing at up to 65 mph.
It humms along like a singer sewing machine at 40-45 mph and could go on forever it seems. The old 216 spinning enough to make 55 and above gets quite noisey. It handles it OK but I don't push it. It definitely likes 40 - 45 best LOL.
That's small potatoes compared to many of the amazing posts in this thread but does show a good dependability for a basically stock 68 yr old truck.