My '51 1/2 ton had 7.50 x 16 rires on it when I bought it, and I ran them for a couple years with no interference problems. They do improve the highway performance. As long as your rims don't have extreme offset or backspacing, they should be OK. Expect your speedometer readings to change a good bit though.

By the way I still have these tires/rims out behind the garage. See Swap Meet.