Bolters,
Isocyanates is the single biggest reason you see few old painters. I know guys who are so sensitized to Isocyantes they can't walk down the sidewalk outside a body shop where Isos are being sprayed. Once lung tissue gets sensitized to it, it's over. Some take a long time to sensitize, some get down almost instantaneously.
Now no one wants to spout the fact that their product has Isos but I do think the coatings industry & dealers should do a better job of schooling customers.