The large Rochester world require a different adapter, but yes, it could be made to work; but why???

If you are looking for reliability, the Stromberg has only one reliability issue, the aluminum throttle body. Once a competant rebuilder has installed bushings to prevent throttle shaft/throttle body wear; they are bullet-proof! And the larger Strombergs came from the factory with roller-bearings which totally eliminated this issue.

If you are hot-rodding the engine, the Strombergs came in a variety of venturii sizes, and were used on G.M.C. V-6's up to 478 CID and EVERYTHING STILL FITS!

The Strombergs have one major disadvantage (shared by the Rochester) when compared to the Holley. Every parts store in the world has Holley parts; and don't carry Stromberg or Rochester parts. But both the Stromberg and Rochester parts are readily available mail order.

We have been selling the Strombergs to Buick, Cadillac, and Packard owners of mid-1930's cars for lots of years, because they are so reliable, and often much less expensive than the original.

But yes, Trans-Dapt probably had an adapter to replace the Stromberg with the larger Rochester.

Jon.

Good carburetion is fuelish hot air
The most expensive carburetor is the wrong one you attempt to modify.
If you truly believe "one size fits all," try walking a mile in your spouse's shoes!
The Carburetor Shop