Patrick,
Don't really chime in here often. I read, search this site, and just get answers. Don't think I'm a "qualified stovebolter" but here goes.
I own and daily ride a 53 1/2 ton. Rain, heat, snow, done it all for the last 2 years now. I will just tell you what I have learned.
I too had long cracked block. Was 216 which ran great. Leaked bad. Used jb weld with great success, but finally gave in to new 235.
55 hydraulic lifter motor, dual webers from T. Langdon, Williams headers, offy intake, dual exhaust, dual 2 chamber mufflers. Runs like a top.
Upgraded to T5 5 speed trans. Awesome upgrade as recommended here by so many. Wanted to keep original pedals and foot start. Upgraded to front discs, and new underfloor mount dual master and bracket. Drums rear, new brake lines throughout (a must). Still have ho 33 rear with 3.90's. Can do 55 super comfortably, 65 the whole way if need be.
A main concern is bump steer. I read about it here, and experienced the white knucke feel. You must get your alignment and front end parts set right. On a bumpy highway or backroad at higher speeds, you could have some serious issues. On that note, seat belts! Yes, I got them. Mounted two bucket seat from a Silverado with seat belts built in. I also have the headrests in case of getting rear ended. Not an original look, but I feel safer. Lots have done that here also.
Good headlights, brake lights a must. LEDs in the back are terrific. I also have nice bright white led backup lights hooked to t5 switch. Electric wipers, a must have. My vacuum wiper system works great, but I am going to scrap it. This week actually.
There's probably tons more, but I thought I would just say what I have been through.
Finally, why not go with a 235? I go.to many hot rod shows and get soo many comments on how cool it is to have kept the 6! Even young ones like it. My 56 is done with big block and I prefer this truck! Actually may finally sell the car.
With that 350, you really may want to go to a new front crossmember. Better ride quality, steering.
My buddy is almost done with his 53 with chassis engineering front end,350, ford rear, aluminum shaft. It's awesome!, but, the six is too!
Have fun, be safe, drive a little farther back than your normal abs equipped car.

My web site has some pics and videos of my truck if interested. Phil...





Phil