Concur with Cletis. I did the 4:10 3rd member upgrade to my 3800 (I have a 235 engine). Top speed I have been able to attain is 72 (going downhill) and 69 on level ground. It runs out of horsepower before it runs out of gears. It will cruise comfortably at 65 MPH now. BUT ... Cletis is also right about the brakes. I keep doubly aware of what's going on at that speed and hope like crazy I do not need to panic brake.
Also, next up is a front axle rebuild (king pins, ball ends, etc). 72 MPH is a little tense

Going to taller gears in either the rear axle or the transmission will tax your 216 or 235 considerably. You will not have a lot of acceleration.
John