If you do choose to run with Silicone fluid, you have to make 100% sure that all of the rubber components are rated for use with it. Most rubber parts made for passenger car and light truck use is designed to be used only with glycol based fluids, silicone fluids can damage them. Also, silicone fluids should never be used in any vehicle that has ABS, as it will cavitate in the ABS module (that isn't a problem with the trucks we deal with, though). It should also be noted that silicone fluids are compressible, which can give a slightly spongy brake feel, especially when the brakes are hot. While it does not absorb moisture (the common reason it's used in vintage vehicles), it also does not dissipate it like glycol does. That allows for any moisture that gets in the system to condense into water droplets at the bottom of the master cylinder and wheel cylinders, causing corrosion.
From a personal experience standpoint, I would not use silicone fluid in anything that did not have it as a factory fill. In a Harley, sure. In my Chevrolet trucks or any of my customers vehicles, no. There's simply no benefit to using it, and several reasons not to.
