As the title says! My personal results:
1965 C-10, 3.73 open rear, 31x10.50x15 drive tires (14.5" loaded radius), three speed SM318 and 230 with a slightly later Monojet. Engine is stock, complete with ultra high mileage and stuck lifter. (I figure at least 400,000 since the head's been off. Low drag rings courtesy of time?) Carburetor should have stock jets, idle mixture tuned lean. Timing bumped up to 8 degrees initial. Had an electric fan and fuel pump at that time, also. Mileage was about 18-20MPG @ 50-55MPH or so.
1966 C-10, 3.08 gov bomb, same drive tires as the '65, 3.11 first Saginaw 4 speed. 350 with Edelbrock #1406 AVS copy, Chinese dual plane intake, flat top pistons, stock profile CS274 cam. About 90,000 on it since it was rebuilt. Vortec heads. Flex fan, electric fuel pump, point and coil. Got 16-17MPG or so on it's first run with the 3.08 gears going about 60MPH. (Didn't get any numbers with the 3.73s)
This was done using google maps to calculate distance, then parking the truck in the same spot and adding fuel up to a dipstick level by weight. The same route more or less was used both times, mixed rural highway/town with some fairly good hills. About 90 miles total.
I'm going to make a 6 gallon strap-in tank to put in the bed next, so I can just weigh the tank to determine fuel used. Should be real accurate and also allow me to do some shorter test runs.
What's your mileage with your truck?
Some of my crap:
1963 C-30 flatbed dually 292/SM420
1965 C-10 LWB fleet 250/column shift 3 speed
1965 C-30 9' stepside 250/SM420/4.10 gears (my DD)
Website I made for my crap:
http://www.66submarine.com