The transmission in a 65 C-10 does not mount to the crossmember.
It hangs by the 4 bolt mounting tabs on the bellhousing. The bellhousing mounts to the rear crossmember. The M21 is longer than the SM420. The SM420 drive shaft bolts directly to the trans and has a slip joint in the front section of the driveshaft. The M21 uses a driveshaft with a splined slip joint on the end that slides into the rear of the trans.
A competent drive line service can make one up for you. You will have to cut a hole in the floor for the shifter, otherwise no other changes are necessary to make this conversion.
Fred


1956 3100 Pickup/Red/350/3sp OD/PS/Disc Brakes
1957 Bel Air Sport Coupe/Red/355/TH350/PS/Disc Brakes
2017 Silverado LT Single Cab SB/Black/5.3/6 Speed Trans
1947 Willys CJ2A w/F-Head engine