I have a 4.10 rear with a T5 in my 3/4 ton. I'd love to tell you my RPM's at each speed but I don't have a tach. Also my speed is not hooked up. I'm guessing I'm at 2,300 r's at 70 mph. I have a chevy 235 and the power is fine.
If you're going highway speeds, just make sure you can slow down and stop.