The "big block" V-6's are very cool. My son has one in his 66 and he as gone so far to procure a spare block to rebuild when the original dies (if it does).
I have grown fond of the motors too. They are something unique that when you pop the hood should get some conversation going.
They are built stout. Big main bearings, lots of metal in those things to hold it together.
If I ever have time I would like to build one with some boost, like a remote turbo, just for fun. With a sheet metal intake and Holley style carb, and homemade headers. Just to be even more different.
The only thing is some rebuild parts are getting a little harder to find, like oversize pistons. You can get customs if you want to spend the money, so that is the only thing stopping you.
We went through my son's motor, changed fluids, put in all new ignition components, filters, stuff like that, and he is just been driving it ever since. He loves it.