Yes, there will be offset/clearance issues with those rims. This acyually applies to any 6 lug GM 4x4 after '88, 'Burb and Blazer after '92, and all 2wd trucks after '99. The lug pattern is the same, though, and you can put the older style offset on the newer trucks with little problems, but not the other way around. This also applies to the S10 for those using S10 parts. The 2wd and 4x4 use different offsets.
BTW- old 6 lug are 7/16" studs, the newer trucks use 14mm. There are lug nuts available to allow for using the later caps with the older stud sizes. I have them on mine, don't really know who made them, I got them from a swap meet vender. They're 1/2" diameter, so I did have to change the studs to the larger size and slightly modify the wheels by making the nut seats larger.
