Yup, big difference
. The main concern I would have is that you will lose in town performance due to the higher gearing. As long as you have a strong running engine and a decent 1rst and 2nd gear, should be ok. I would also suggest that you not go too big wth the tires, as that will affect the overall final ratio. Bigger tires give the same effect as runing a higher gear, which requires more torque to get the load moving.
