The challenge is getting to and loosening the factory hose clamps on the rubber hose, that connects the filler neck, to the spout on the fuel tank. Access and visibility is decreased, due to the tight quarters, but it is not that difficult with some patience and the tools.
I have found it is easiest to empty the tank first and remove it by tipping it up from the passenger side, thus allowing the filler spout, to come out from under the inner lip of the cab. The process is easier with two, but one can do it. Obviously, you will need to remove the bolts, that secure the tanks straps, to the tank cradles and push them out of the way, as well as, remove the fuel line from the sender, before removing the tank.
Upon removal, it is a good time to access the cab corners and behind the tank, for a good cleaning & vacuuming. Also, make sure your cradle pads are in place, prior to replacing the tank, to avoid in metal-on-metal contact between the tank and the cradles, thus eliminating any premature wear. This is also a good time to check the pliability of the grommet, where the fuel line penetrates the floor.