I have a 2007 6.0 in my 1952 3100 and asked the same question you did here.After talking with Mark at Street and performance 479-394-5711
http://www.hotrodlane.cc/.He said it can be done but would require a lot of time and you need to know what you are doing.I wanted a very drivable zero problem and reliable truck anyone could drive.So I went with there harness and they reprogrammed the computer also.The wire harness Install was very easy and worked with no problems.
