I have been running 12v and 6v Pertronix ignitions on 235s and 261s without problems for over 10 years. I will most likely put one on the 6v positive ground 270 GMC engine in my COE.

The grounding consideration mentioned by Wrenchbender Ret explained why I often had hesitation at high rpm.

In a 12v 216/235/261 set-up, if you do not have a coil with 3-4 ohms resistance, you are supposed to use the ballast resistor (the Pertronix Flamethrower coil has 3 ohms of resistance).