I have a 2.73 rear in my '73 Monte Carlo , while it keeps the rpm down and allows for very quiet running , the gearing is so tall that the car has little "get up and go" . I've pulled a small caravan with it and it was working hard all the time , regardless of speed.
I think of a truck as being a tool , so it needs to be able to tow a load , carry a load and do it without too much difficulty.
So ......... I think a 350 with a 700r4 and a 3.7 or even a 4.1 rear would be a very handy combo. The overdrive would bring the road gear back close to 3.0.
Great off the line pull and a long leg for the open road.