Let's see if I can get you some answers.....
Engine--original 216
Will sit and idle all day without a hickup.
Will run at about 40 mph for 1 to 2 miles before missing then quiting.
Have the same problem whether engine is well warmed up or cold.
I just fidget for 20-30 minutes.
When it restarts, it requires a period of cranking with carb at full choke.
I have a fuel filter between tank and pump and one between pump and carb.
I have not checked for fuel in carb or spark when I have the problem.
Thanks for any additional help.