The Stovebolt Site Forums The Shop Area Engine Shop Can I use a 250 with my stock tranny and closed driveline?

I have a 1950 1/2 ton Chevrolet pickup with stock drivetrain. I am pulling the locked up 216.5 and have access to a good 250. I would really like to keep my stock transmission and rearend for now. Can I make a 250 work? What mods would I need to do? Thanks for the help.