It might pull a little stronger with duals, but I believe you'd have to do some pretty extensive intake and/or port mods to take advantage of the bigger carb. Even then, you'd have to be very careful not to over-rev it with the extra flow capability. I've got a 351 engine in a 1960 GMC American LaFrance fire truck, but it's way down on the project list behind some smaller stovebolts. It runs a really tiny Stromberg 2-barrel, and it seems to be plenty of carburetor for that engine.
Jerry