what V6?
GM? Ford? Dodge?
If GM, which one?
60 degree V6's - 2.8 liter, 3.1 liter, 3.4 liter, 3.4 liter twin cam)
90 degree V6's - 225 Buick, 229 Chevrolet, (3.8 liter) 231 Buick (3.8 liter), 4.1 Buick, 4.3 Chevrolet, 305 V6
Lets assume the 4.3 liter V6. Forget milling the heads, start with a set of Vortec heads (96 and later). Since your talking HEI, your running a carb. Use a dual plane intake and a holley 390 cfm carb. There are plenty of cam options out there. I have seen this engine putting out 300hp without breaking the bank. Other than that, think of the engine as a SBC with cylinders 6 & 7 removed.