If trying to use 6" wide 22.5" wheels the books don't want you to put 9R22.5 tires on them (closest readily available and suitable size), they really need 6.75" wide rims, or even 7.5" rims.
That said, I have 9r22.5 tires on my 6" wide rims, they don't rub each other on the rear duals, they mounted fine, and look good.
However, I don't expect to load them to the max, or even half the weight they are designed to carry, so I expect they will be fine, but I'll keep an eye on them.
Grigg