I haven't done it, but I have often dreamed of using the cab and front sheetmetal from a 1.5 to 2 ton truck on a 4wd project. With the larger fenders and wheel openings, it should work great with larger tires. I would put a flatbed on it with removable high-seats so I could use it to spotlight rabbits, coyotes, ect. It would also make a fun river toy.
When you do this, take pictures and keep us informed on the progress.