Hi Bob,
Welcome aboard and congrats! Is the stock frame in good shape? If so, there are ways to adapt more modern front clips (Camaro, Nova, etc.) to the stock frame, or use a Mustang II style kit. For the rear, there are upgrades available for leaf, 4-link and others.
I'm running an S10 Xtreme rear axle on leaf springs, with deep dish rear wheels (for that way cool look!), which requires tubbing the bed a bit to fit the big meats.
Is there a reason you want an S10 frame? I've seen it done, but from what I've heard, it isn't an easy swap.
Anywho, I'm sure you came to the right place for advice!
Antny