Microbe-
Welcome to the Stovebolt! Plenty of help around this garage.
The first question might be: what do you want in the end? Do you want more performance or a daily driver with similar characteristics, but less blue smoke. How much of a factor is cost? Are you mechanically inclined (do-it-yourself) or are you farming this out? Is this the only part of your truck you want to change? These questions may help you focus on simple engine machining, replacement, or upgrades.
OK, with a handle like "Microbe" I'm intrigued. What do you do for living?