O.K. , my .02 , I have a 1949 3100 series work truck , poorly rebuilt 235 and SN420 gearbox , Patric's 3.55 gears in the Torque Tube and 29" tall LT205/85R16 tires on it , Rochester " B " series carby with no mods , used to have split manifold & twice pipes , no muffler but the manifold cracked so now it's a single exhaust again , I have plenty of power off the line unless fully loaded (it's a auto shop work truck) , cruises easily at 60 ~ 65 and I still tow cars with it haul scrap etc. .
It's fine for long distances , 300 mile trips out into the desert are routine for this truck .
I really noticed the loss of power between the split manifold and the single one and plan to replace the exhaust manifold withone split by Kansas Kustoms , plus the Offy dual carby intake with two Rochester " B " series carbies as I like them .
Go with this setup as you've planned , it'll go fine on freeway or in the hills plus reliability
will be good , don't use bias ply tires though , you'll be sorry if you do on a daily driver .
