Sounds like the repair I did on my frame. The bed wood laid on top of the frame hump and rusted it away. I welded in a rounded shape to the top flange.

A large truck frame built of alloy steel has special considerations to avoid weakening the frame. But an AD frame is made of mild steel, so as long as you're in a low stress area (like the top flange of the frame hump) there's no special techniques needed. Just make sure you get full penetration and avoid sharp corners. A large truck frame built of alloy steel has special considerations to avoid weakening the frame.
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Kevin
1951 Chevy 3100 work truck
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1929 Ford pickup restored from the ground up. | 1929 Ford Special Coupe (First car)
Busting rust since the mid-60's
If you're smart enough to take it apart, you darn well better be smart enough to put it back together.