I'm using a pressure-oiled 235/261 crankshaft with the rod journals offset-ground to get a 4 5/16" stroke. I'm planning to use a Nissan 2.4L 4 cylinder connecting rod that's almost 6.5" center to center that uses a connecting rod bearing 1.967" in diameter. Either OEM connecting rods or tool steel NASCAR style rods are available with those dimensions. With a little custom machining, that shaft can be fitted to 216, 235, or 261 blocks. A pretty wide variety of pistons can be adapted, to include standard bore 235 pistons in the "216", Ford 223 cubic inch inline six pistons in the "235" and the Buick pistons I mentioned in "261" blocks. There are a few other crankshaft/rod/piston combinations possible, with varying amounts of custom machining involved.
Jerry