If they are good and tight like they should be then no problems.
You may consider more caster when you do your front end alignment, it should help keep you in the center of the road a bit and not wander so much.

Brakes would be the big thing to worry about.
Probably want a dual master cylinder for safety reasons at speed. That complicates a stock hydrovac system, because you now need two..
For a power booster, I have to recommend a hydroboost like the new diesel trucks.
Without a full load the big truck brakes should be adequate at speed. However I hear that people who use Kevlar shoes like them, I would look into that.

Check my pictures below for some ideas.
Search for hydroboost for more info.
Might want to start a new thread with your plans and ideas so we can help you better understand your options.

Grigg


1951 GMC 250 in the Project Journals
1948 Chevrolet 6400 - Detroit Diesel 4-53T - Roadranger 10 speed overdrive - 4 wheel disc brakes
1952 Chevrolet 3800 pickup
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"First, get a clear notion of what you desire to accomplish, and then in all probability you will succeed in doing it..." -Henry Maudslay-